Endocrine Abstracts

: Lymphoma is one of the rare causes of bilateral adrenal gland enlargement that require a high index of suspicion for diagnosis. We present a case of 80-year-old lady referred by her GP for further evaluation after presenting with lower abdominal discomfort and weight loss for which she had a CT scan that revealed bilateral adrenal gland masses (60 HU) with the right adrenal gland measures 61 mm in diameter with distal ileal thickness and regional lymphadenopathy. She has no ...

A 45-year-old female presented with recurrent episodes of neuroglycopaenic symptoms 6 years after Roux-en-Y gastric bypass surgery. Her symptoms occurred during both the fasting and postprandial state. She had a history of Rheumatoid Arthritis. Her symptoms did not response to a complex carbohydrate diet or Acarbose use.Whipple’s triad was demonstrated during a 72 h fast; symptomatic hypoglycaemia (1.8 mmol/l) occurred which resolved with glucose ad...

Primary Aldosteronism (PA) is caused by autonomous aldosterone production from the adrenal cortex (due to hyperplasia, adenoma or rarely carcinoma) and diagnosis is confirmed by elevated plasma aldosterone level with suppressed renin activity and localized further by CT scan of the adrenal glands and selective adrenal venous sampling (AVS) if required. On the other hand, Addison disease (also known as primary adrenal insufficiency) which represents the other face of the coin i...

Introduction: Adrenal insufficiency is characterized by inadequate ¬glucocorticoid production owing to destruction of the adrenal cortex or lack of adrenocorticotropic hormone stimulation. Patients can present with an insidious onset of symptoms, or acutely in adrenal crisis, which requires prompt recognition and treatment. Chronic glucocorticoid therapy is the most common cause of adrenal insufficiency. We present a case with an adrenal insufficiency caused by Itraconazo...

Dopamine agonists (DA) are first line therapy for Prolactinoma which normalises prolactin(PRL) level in 80% of cases at a median weekly dose of 1 mg. An accepted criterion of pharmacological resistance to DA is failure to normalize PRL levels. We report a case of aggressive macroprolactinoma that required 7 mg of Cabergoline to reduce prolactin despite radiological evidence of tumour shrinkage. A 42 year old male presented with a bitemporal field defect. Imaging confirmed an i...

30 yr/F, presented with C/O of palpitations, heat intolerance, significant unintentional weight loss with bulging of eyes and diplopia on extremes of vision. She had a background history of asthma, PCOS, obesity and difficulty in conceiving. OE, there was a smooth painless goiter. TFTs at diagnosis: TSH <0.05, T4=83, T3 >30.8 and TSH receptor antibody level (TRAB) of 9.0. She developed skin reaction to both Carbimazole and PTU, hence treated with total thyroidectomy wi...